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Article

Whole genome sequencing of 378 prostate cancer metastases reveals tissue selectivity for mismatch deficiency with potential therapeutic implications.

Genome medicine - 20 Mar 2025

Vis Daniel J, Palit Sander A L, Corradi Marie, Cuppen Edwin, Mehra Niven, Lolkema Martijn P, Wessels Lodewyk F A, van der Heijden Michiel S, Zwart Wilbert, Bergman Andries M

Abstract excerpt

BACKGROUND: Survival of patients with metastatic castration-resistant prostate cancer (mCRPC) depends on the site of metastatic dissemination. METHODS: Patients with mCRPC were prospectively included in the CPCT-02 metastatic site biopsy study. We evaluated whole genome sequencing (WGS) of 378 mCRPC metastases to understand the genetic traits that affect metastatic site distribution. RESULTS: Our findings...

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Share to Aged
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Metastasis

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Share to Prostatic Neoplasms, Castration-Resistant

Share to Receptors, Androgen

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Source

Open in PubMed Open full text

Identifiers

PMID: 40114169
DOI: 10.1186/s13073-025-01445-5
PMCID: PMC11927350

Genes

AR
JAK1
PIK3CA
RB1
RNF43
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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