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Article

The Mutational Landscape of Metastatic Castration-sensitive Prostate Cancer: The Spectrum Theory Revisited.

European urology - 1 Nov 2021

Deek Matthew P, Van der Eecken Kim, Phillips Ryan, Parikh Neil R, Isaacsson Velho Pedro, Lotan Tamara L, Kishan Amar U, Maurer Tobias, Boutros Paul C, Hovens Christopher, Abramowtiz Matthew, Pollack Alan, Desai Neil, Stish Bradley, Feng Felix Y, Eisenberger Mario, Carducci Michael, Pienta Kenneth J, Markowski Mark, Paller Channing J, Antonarakis Emmanuel S, Berlin Alejandro, Ost Piet, Tran Phuoc T

Abstract excerpt

BACKGROUND: Emerging data suggest that metastasis is a spectrum of disease burden rather than a binary state, and local therapies, such as radiation, might improve outcomes in oligometastasis. However, current definitions of oligometastasis are solely numerical. OBJECTIVE: To characterize the somatic mutational landscape across the disease spectrum of metastatic castration-sensitive prostate cancer (mCSPC) to...

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Identifiers

PMID: 33419682
DOI: 10.1016/j.eururo.2020.12.040
PMCID: PMC10262980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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