Article
Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2023
Johnson Margaret, Bell April, Lauing Kristen L, Ladomersky Erik, Zhai Lijie, Penco-Campillo Manon, Shah Yajas, Mauer Elizabeth, Xiu Joanne, Nicolaides Theodore, Drumm Michael, McCortney Kathleen, Elemento Olivier, Kim Miri, Bommi Prashant, Low Justin T, Memon Ruba, Wu Jennifer, Zhao Junfei, Mi Xinlei, Glantz Michael J, Sengupta Soma, Castro Brandyn, Yamini Bakhtiar, Horbinski Craig, Baker Darren J, Walunas Theresa L, Schiltz Gary E, Lukas Rimas V, Wainwright Derek A
Abstract excerpt
PURPOSE: Glioblastoma (GBM) is the most common aggressive primary malignant brain tumor in adults with a median age of onset of 68 to 70 years old. Although advanced age is often associated with poorer GBM patient survival, the predominant source(s) of maladaptive aging effects remains to be established. Here, we studied intratumoral and extratumoral relationships between adult patients with GBM and mice with...
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