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Article

Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers

4 Jun 2019

Abstract excerpt

Abstract Immunotherapies can mediate regression of human tumors with high mutation rates, but responses are rarely observed in patients with common epithelial cancers. This raises the question of whether patients with these common cancers harbor T lymphocytes that recognize mutant proteins expressed by autologous tumors that may represent ideal targets for immunotherapy. Using high-throughput immunologic...

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PMID: 31164343
DOI: 10.1158/2159-8290.cd-18-1494

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