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Article

Central Alteration in Peripheral Neuropathy of Trembler-J Mice: Hippocampal pmp22 Expression and Behavioral Profile in Anxiety Tests.

Biomolecules - 19 Apr 2021

Damián Juan Pablo, Vázquez Alberdi Lucia, Canclini Lucía, Rosso Gonzalo, Bravo Silvia Olivera, Martínez Mariana, Uriarte Natalia, Ruiz Paul, Calero Miguel, Di Tomaso María Vittoria, Kun Alejandra

Abstract excerpt

Charcot-Marie-Tooth (CMT) type 1 disease is the most common human hereditary demyelinating neuropathy. Mutations in pmp22 cause about 70% of all CMT1. Trembler-J (TrJ/+) mice are an animal model of CMT1E, having the same spontaneous pmp22 mutation that is found in humans. We compared the behavior profile of TrJ/+ and +/+ (wild-type) in open-field and elevated-plus-maze anxiety tests. In these tests, TrJ/+ showed...

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PMID: 33921657
DOI: 10.3390/biom11040601
PMCID: PMC8074002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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