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Article

Actin limits egg aneuploidies associated with female reproductive aging

20 Jan 2023

Abstract excerpt

Aging-related centromeric cohesion loss underlies premature separation of sister chromatids and egg aneuploidy in reproductively older females. Here, we show that F-actin maintains chromatid association after cohesion deterioration in aged eggs. F-actin disruption in aged mouse eggs exacerbated untimely dissociation of sister chromatids, while its removal in young eggs induced extensive chromatid separation...

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PMID: 36662854
DOI: 10.1126/sciadv.adc9161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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