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Centrosome and microtubule functions and dysfunctions in meiosis: implications for age-related infertility and developmental disorders

22 Apr 2015

Abstract excerpt

The effects of oocyte aging on meiotic spindle dynamics have been well recognised, but the mechanisms underlying the effects are not well understood. In this paper we review the role of centrosomes and the microtubule cytoskeleton in meiotic spindle formation and maintenance, and the impact of oocyte aging on spindle integrity resulting in centrosome and microtubule dysfunctions that are associated with...

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PMID: 25903261
DOI: 10.1071/rd14493

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