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Article

Age‐dependent aneuploidy in mammalian oocytes instigated at the second meiotic division

3 Jun 2022

Abstract excerpt

Ageing severely affects the chromosome segregation process in human oocytes resulting in aneuploidy, infertility and developmental disorders. A considerable amount of segregation errors in humans are introduced at the second meiotic division. We have here compared the chromosome segregation process in young adult and aged female mice during the second meiotic division. More than half of the oocytes in aged mice...

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PMID: 35665589
DOI: 10.1111/acel.13649

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