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Article

Kinetochore microtubule establishment is defective in oocytes from aged mice

11 Feb 2014

Abstract excerpt

Errors in chromosome segregation in mammalian oocytes increase in number with advancing maternal age, and are a major cause of pregnancy loss. Why chromosome segregation errors are more common in oocytes from older females remains poorly understood. In mitosis, accurate chromosome segregation is enabled by attachment of kinetochores to microtubules from appropriate spindle poles, and erroneous attachments...

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PMID: 24553117
DOI: 10.4161/cc.28046

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