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Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo

24 Feb 2023

Abstract excerpt

Abstract Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, is decreased in models of DC. Herein, using telomerase reverse transcriptase null (Tert−/−) mice with critically short telomeres, we investigated the...

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PMID: 36826621
DOI: 10.1007/s11357-023-00752-2

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