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Article

Pathogen exposure misclassification can bias association signals in GWAS of infectious diseases when using population-based common control subjects.

American journal of human genetics - 2 Feb 2023

Duchen Dylan, Vergara Candelaria, Thio Chloe L, Kundu Prosenjit, Chatterjee Nilanjan, Thomas David L, Wojcik Genevieve L, Duggal Priya

Abstract excerpt

Genome-wide association studies (GWASs) have been performed to identify host genetic factors for a range of phenotypes, including for infectious diseases. The use of population-based common control subjects from biobanks and extensive consortia is a valuable resource to increase sample sizes in the identification of associated loci with minimal additional expense. Non-differential misclassification of the outcome...

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Identifiers

PMID: 36649706
DOI: 10.1016/j.ajhg.2022.12.013
PMCID: PMC9943744

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