Article

Correcting for population stratification reduces false positive and false negative results in joint analyses of host and pathogen genomes

2017-12-19

Abstract excerpt

Studies of host genetic determinants of pathogen sequence variation can identify sites of genomic conflicts, by highlighting variants that are implicated in immune response on the host side and adaptive escape on the pathogen side. However, systematic genetic differences in host and pathogen populations can lead to inflated type I (false positive) and type II (false negative) error rates in genome-wide association...

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Literature Corpus work: 12fd0a67-2553-5a0a-b1d4-99b623fdb52e
DOI: 10.1101/232900

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