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Article

Candidate genes versus genome-wide associations: which are better for detecting genetic susceptibility to infectious disease?

Proceedings. Biological sciences - 22 Apr 2011

Amos W, Driscoll E, Hoffman J I

Abstract excerpt

Technological developments allow increasing numbers of markers to be deployed in case-control studies searching for genetic factors that influence disease susceptibility. However, with vast numbers of markers, true 'hits' may become lost in a sea of false positives. This problem may be particularly acute for infectious diseases, where the control group may contain unexposed individuals with susceptible genotypes....

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Identifiers

PMID: 20926441
DOI: 10.1098/rspb.2010.1920
PMCID: PMC3049081

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