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Article

Contaminant DNA in bacterial sequencing experiments is a major source of false genetic variability.

BMC biology - 2 Mar 2020

Goig Galo A, Blanco Silvia, Garcia-Basteiro Alberto L, Comas Iñaki

Abstract excerpt

BACKGROUND: Contaminant DNA is a well-known confounding factor in molecular biology and in genomic repositories. Strikingly, analysis workflows for whole-genome sequencing (WGS) data commonly do not account for errors potentially introduced by contamination, which could lead to the wrong assessment of allele frequency both in basic and clinical research. RESULTS: We used a taxonomic filter to remove contaminant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32122347
DOI: 10.1186/s12915-020-0748-z
PMCID: PMC7053099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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