Article

Extreme Sampling for Genetic Rare Variant Association Analysis of Dichotomous Traits with Focus on Infectious Disease Susceptibility

2021-12-02

Abstract excerpt

As genomic sequencing becomes more accurate and less costly, large cohorts and consortiums of cohorts are providing high power for rare variant association studies for many conditions. When large sample sizes are not attainable and the phenotype under study is continuous, an extreme phenotypes design can provide high statistical power with a small to moderate sample size. We extend the extreme phenotypes design to...

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Literature Corpus work: e771e6dd-7dc9-5416-bb70-c4f36fb2fe04
DOI: 10.1101/2021.12.02.470949

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