Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss.

Nature communications - 3 May 2023

Rüland Laura, Andreatta Francesco, Massalini Simone, Chuva de Sousa Lopes Susana, Clevers Hans, Hendriks Delilah, Artegiani Benedetta

Abstract excerpt

Fibrolamellar carcinoma (FLC) is a lethal primary liver cancer, affecting young patients in absence of chronic liver disease. Molecular understanding of FLC tumorigenesis is limited, partly due to the scarcity of experimental models. Here, we CRISPR-engineer human hepatocyte organoids to recreate different FLC backgrounds, including the predominant genetic alteration, the DNAJB1-PRKACA fusion, as well as a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Cell Transdifferentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocytes

Share to HSP40 Heat-Shock Proteins

Share to Liver Neoplasms

Share to Organoids

Share to Tumor Suppressor Proteins

Share to Ubiquitin Thiolesterase

Source

Open in PubMed Open full text

Identifiers

PMID: 37137901
DOI: 10.1038/s41467-023-37951-6
PMCID: PMC10156813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss.PMID 37137901Read ↗

Expression of DNAJB1-PRKACA oncogene suppresses the differentiation potential of liver progenitor organoids towards a hepatocyte lineageSemantic proximity Read ↗

<i>DNAJB1</i> - <i>PRKACA</i> fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinomaSemantic proximity Read ↗

CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma.Semantic proximity Read ↗

Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer In Vivo and In VitroSemantic proximity Read ↗

CDK7 is a Novel Therapeutic Vulnerability in Fibrolamellar CarcinomaSemantic proximity Read ↗

Evaluation of PRKACA as a Therapeutic Target for Fibrolamellar CarcinomaSemantic proximity Read ↗

A Human Multi-Lineage Hepatic Organoid Model for Liver FibrosisSemantic proximity Read ↗

Liver cancer multiomics reveals diverse protein kinase A disruptions convergently produce fibrolamellar hepatocellular carcinomaSemantic proximity Read ↗

A human multi-lineage hepatic organoid model for liver fibrosis.Semantic proximity Read ↗

Fibrotic Phenotype in CRISPR knockout p53 of Hepatic Organoids within a Pro-Carcinogenic MicroenvironmentSemantic proximity Read ↗

Organoids for the Study of Liver CancerSemantic proximity Read ↗

Human liver organoids for disease modeling of fibrolamellar carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.