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Article

FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted

20 Apr 2021

Abstract excerpt

BACKGROUND & AIMS: Cholangiocarcinoma (CCA) is a neoplasia of the biliary tract driven by genetic, epigenetic and transcriptional mechanisms. Herein, we investigated the role of the transcription factor FOSL1, as well as its downstream transcriptional effectors, in the development and progression of CCA. METHODS: FOSL1 was investigated in human CCA clinical samples. Genetic inhibition of FOSL1 in human and mouse...

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PMID: 33887357
DOI: 10.1016/j.jhep.2021.03.028

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