Article

3D human retinal organoid model for the study of early diabetic retinopathy

2023-09-05

Abstract excerpt

Diabetic retinopathy (DR) is a significant complication of diabetes and a primary cause of visual impairment among working-age individuals. DR is a degenerative condition in which hyperglycaemia results in morphological and functional changes in certain retinal cells. Existing treatments mainly address the advanced stages of the disease, which involve vascular defects such as macular edema or neovascularization. H...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d4d06f56-8533-5190-969e-dada0bf9be46
DOI: 10.1101/2023.09.04.556258

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

3D human retinal organoid model for the study of early diabetic retinopathyDOI 10.1101/2023.09.04.556258Read

Unveiling the Cellular and Molecular Mechanisms of Diabetic Retinopathy with Human Retinal OrganoidsSemantic proximity Read

Retinal Organoids: A Human Model System for Development, Diseases, and Therapies.Semantic proximity Read

Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental modelsSemantic proximity Read

Advances in the Molecular Pathophysiology and Emerging Therapeutic Strategies for Diabetic RetinopathySemantic proximity Read

Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoidsSemantic proximity Read

Reproducing diabetic retinopathy features using newly developed human induced‐pluripotent stem cell‐derived retinal Müller glial cellsSemantic proximity Read

Revisiting Retinal Degeneration Hallmarks: Insights from Molecular Markers and Therapy PerspectivesSemantic proximity Read

Human Retina-on-a-Chip: Merging Organoid and Organ-on-a-Chip Technology to Generate Complex Multi-Layer Tissue ModelsSemantic proximity Read

Remodeling of Retinal Architecture in Diabetic Retinopathy: Disruption of Ocular Physiology and Visual Functions by Inflammatory Gene Products and PyroptosisSemantic proximity Read

Role of Oxidative Stress in Retinal Disease and the Early Intervention Strategies: A ReviewSemantic proximity Read

The Healthy and Diseased Retina Seen through Neuron-Glia InteractionsSemantic proximity Read

Single-cell transcriptomic analysis revealing changes in retinal cell subpopulation levels and the pathways involved in diabetic retinopathySemantic proximity Read