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Article

Vitamin C boosts DNA demethylation in TET2 germline mutation carriers.

Clinical epigenetics - 14 Jan 2023

Taira Aurora, Palin Kimmo, Kuosmanen Anna, Välimäki Niko, Kuittinen Outi, Kuismin Outi, Kaasinen Eevi, Rajamäki Kristiina, Aaltonen Lauri A

Abstract excerpt

BACKGROUND: Accurate regulation of DNA methylation is necessary for normal cells to differentiate, develop and function. TET2 catalyzes stepwise DNA demethylation in hematopoietic cells. Mutations in the TET2 gene predispose to hematological malignancies by causing DNA methylation overload and aberrant epigenomic landscape. Studies on mice and cell lines show that the function of TET2 is boosted by vitamin C....

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Source

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Identifiers

PMID: 36639817
DOI: 10.1186/s13148-022-01404-6
PMCID: PMC9840351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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