Article
Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma.
Haematologica - 1 Dec 2013
Asmar Fazila, Punj Vasu, Christensen Jesper, Pedersen Marianne T, Pedersen Anja, Nielsen Anders B, Hother Christoffer, Ralfkiaer Ulrik, Brown Peter, Ralfkiaer Elisabeth, Helin Kristian, Grønbæk Kirsten
Abstract excerpt
The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is regulated. Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers an...
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