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Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restoration

16 Mar 2020

Abstract excerpt

BACKGROUND: Vitamin C suppresses leukaemogenesis by modulating Tet methylcytosine dioxygenase (TET) activity. However, its beneficial effect in the treatment of patients with acute myeloid leukaemia (AML) remains controversial. In this study, we aimed to identify a potential predictive biomarker for vitamin C treatment in AML. METHODS: Gene expression patterns and their relevance to the survival of AML patients...

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PMID: 32203209
DOI: 10.1038/s41416-020-0788-8

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