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Article

Epigenetic reprogramming of melanoma cells by vitamin C treatment

28 Apr 2015

Abstract excerpt

BACKGROUND: The loss of 5-hydroxymethylcytosine (5hmC) has been identified as a novel epigenetic hallmark for melanoma. One of the known mechanisms underlying the loss of 5hmC is the decrease in expression of ten-eleven translocation family dioxygenase (TET) genes, which encode enzymes that catalyze the generation of 5hmC. Overexpressing TET2 was shown to partially reestablish a normal 5hmC profile in melanoma...

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PMID: 25977731
DOI: 10.1186/s13148-015-0087-z

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