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Article

Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia.

Leukemia - 1 Jan 2018

Mingay M, Chaturvedi A, Bilenky M, Cao Q, Jackson L, Hui T, Moksa M, Heravi-Moussavi A, Humphries R K, Heuser M, Hirst M

Abstract excerpt

The genomes of myeloid malignancies are characterized by epigenomic abnormalities. Heterozygous, inactivating ten-eleven translocation 2 (TET2) mutations and neomorphic isocitrate dehydrogenase (IDH) mutations are recurrent and mutually exclusive in acute myeloid leukaemia genomes. Ascorbic acid (vitamin C) has been shown to stimulate the catalytic activity of TET2 in vitro and thus we sought to explore its...

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Source

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Identifiers

PMID: 28663574
DOI: 10.1038/leu.2017.171
PMCID: PMC5770587

Genes

RUNX1
TET2
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia.PMID 28663574Read ↗

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