Article
Enriched clonal hematopoiesis in seniors with dietary vitamin C inadequacy.
Clinical nutrition ESPEN - 1 Dec 2021
Chen Jiaqi, Nie Daijing, Wang Xinyu, Wang Lei, Wang Fang, Zhang Yang, Chen Xue, Cao Panxiang, Li Minghua, Ma Xiaoli, Yu Tongtong, Zhou Xiaosu, Tian Wenjun, Zhang Yu, Li Yu, Tan Yincheng, Sun Wenli, Fang Jiancheng, Liu Mingyue, Xu Wen, Liu Hongxing
Abstract excerpt
BACKGROUND: The anti-cancer effect of vitamin C (VC) has long been speculated, but studies yielded inconsistency. Recent studies reported that supraphysiological concentration of VC have therapeutic or prevention effects for myeloid malignancies with certain mutation signatures. There was a notable proportion of DAT (i.e., DNMT3A, ASXL1, and TET2) and dozens of other genes that mutate in age-related clonal...
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