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Article

Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks

17 Feb 2004

Abstract excerpt

Mechanical unloading of the heart with a left ventricular assist device (LVAD) significantly decreases mortality in patients with heart failure. Moreover, it provides a human model to define the critical regulatory genes governing myocardial remodeling in response to significant reductions in wall stress. Statistical analysis of a gene expression library of 19 paired human heart samples harvested at the time of...

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Share to Cardiac Structural Anomalies and Repair
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Share to Mechanical Circulatory Support Devices

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Identifiers

PMID: 14872006
DOI: 10.1152/physiolgenomics.00004.2004

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