SATB2, coordinated with CUX1, regulates IL-1β-induced senescence-like phenotype in endothelial cells by fine-tuning the atherosclerosis-associated p16INK4a expression.

doi:10.1111/acel.13765

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

SATB2, coordinated with CUX1, regulates IL-1β-induced senescence-like phenotype in endothelial cells by fine-tuning the atherosclerosis-associated p16INK4a expression.

Aging cell - 1 Feb 2023

Wu Ting, Wu Yuwei, Jiang Danli, Sun Wei, Zou Meijuan, Vasamsetti Sathish Babu, Dutta Partha, Leers Steven A, Di Wu, Li Gang

Abstract excerpt

Genome-wide association studies (GWAS) have validated a strong association of atherosclerosis with the CDKN2A/B locus, a locus harboring three tumor suppressor genes: p14ARF , p15INK4b , and p16INK4a . Post-GWAS functional analysis reveals that CUX is a transcriptional activator of p16INK4a via its specific binding to a functional SNP (fSNP) rs1537371 on the atherosclerosis-associated CDKN2A/B locus, regulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Endothelial Cells

Share to Homeodomain Proteins

Share to Matrix Attachment Region Binding Proteins

Share to Repressor Proteins

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 36633253
DOI: 10.1111/acel.13765
PMCID: PMC9924951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SATB2, coordinated with CUX1, regulates IL-1β-induced senescence-like phenotype in endothelial cells by fine-tuning the atherosclerosis-associated p16INK4a expression.PMID 36633253Read ↗

Post-GWAS functional analysis identifies CUX1 as a regulator of p16INK4a and cellular senescenceSemantic proximity Read ↗

Cathepsin L induces cellular senescence by upregulating CUX1 and p16INK4aSemantic proximity Read ↗

ZONAB regulates DNA methylation and mitochondrial function to control endothelial cell senescenceSemantic proximity Read ↗

Endothelial expression of ZBTB16 protects against cardiac agingSemantic proximity Read ↗

PCBP2 Regulates p16INK4a-Dependent Cellular Senescence in Response to Iron.Semantic proximity Read ↗

Sex-Specific X-Chromosome Gene Expression in Intracranial AneurysmsSemantic proximity Read ↗

Alteration of E2F2 Expression in Governing Endothelial Cell SenescenceSemantic proximity Read ↗

Targeting STOX1 in the therapy of preeclampsia.Semantic proximity Read ↗

MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemiaSemantic proximity Read ↗

9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells.Semantic proximity Read ↗

SOX17 Regulates Nestin/p16INK4a Axis to Mitigate Endothelial Senescence in Pulmonary Arterial HypertensionSemantic proximity Read ↗

ZHX2 alleviates vascular remodeling and smooth muscle cell proliferation by transcriptional regulation of GADD45GSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.