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Article

PCBP2 Regulates p16INK4a-Dependent Cellular Senescence in Response to Iron.

Aging cell - 1 Dec 2025

Yan Shaoyang, Lu Lili, Wu Yuwei, Du Zewen, Johny Ebin, Dutta Partha, Li Gang

Abstract excerpt

Recently, we have identified rs1333046 as one of the candidate functional single nucleotide polymorphisms (fSNPs) on the atherosclerosis-associated CDKN2A/B locus. However, how rs1333046 influences the pathogenesis of and susceptibility to atherosclerosis is unknown. In this work, we demonstrate that rs1333046 is part of a cis-regulatory element (cis-RE) that regulates p16INK4a and p16INK4a-dependent cellular...

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Topics

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Share to NF-kappa B
Share to CD40 Antigens
Share to Cellular Senescence
Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Gene Expression Regulation
Share to Human Umbilical Vein Endothelial Cells
Share to Iron
Share to RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 41216990
DOI: 10.1111/acel.70283
PMCID: PMC12686567

Genes

PCBP2
CD40
FTL
CDKN2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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