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Article

Cathepsin L induces cellular senescence by upregulating CUX1 and p16INK4a

18 Jun 2024

Abstract excerpt

Cathepsin L (CTSL) has been implicated in aging and age-related diseases, such as cardiovascular diseases, specifically atherosclerosis. However, the underlying mechanism(s) is not well documented. Recently, we demonstrated a role of CUT-like homeobox 1 (CUX1) in regulating the p16INK4a-dependent cellular senescence in human endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) via its binding to an...

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PMID: 38944813
DOI: 10.18632/aging.205955

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