Article

ZONAB regulates DNA methylation and mitochondrial function to control endothelial cell senescence

2025-11-21

Abstract excerpt

<h4>Summary</h4> Regulation of the endothelial stress response is important for blood vessel homeostasis and angiogenesis, processes disrupted in common vascular diseases and ageing. Here, we discovered that the Y-box factor ZONAB (ZO-1-associated nucleic acid binding protein; YBX3 ), a gene associated with risk loci for severe vascular disorders, regulates endothelial homeostasis and angiogenesis. By combining...

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Literature Corpus work: 0ab91b10-cda7-5361-a01e-cdc6d6dd7b18
DOI: 10.1101/2025.11.20.689552

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