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Post-GWAS functional analysis identifies CUX1 as a regulator of p16INK4a and cellular senescence

17 Feb 2022

Abstract excerpt

Abstract Accumulation of senescent cells with age is an important driver of aging and age-related diseases. However, the mechanisms and signaling pathways that regulate senescence remain elusive. In this report, we performed post-genome-wide association studies (GWAS) functional studies on the CDKN2A/B locus, a locus known to be associated with multiple age-related diseases and overall human lifespan. We...

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PMID: 37117763
DOI: 10.1038/s43587-022-00177-0

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