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Analysis of fragment ends in plasma DNA from patients with cancer

2021-04-27

Abstract excerpt

Fragmentation patterns observed in plasma DNA reflect chromatin accessibility in contributing cells. Since DNA shed from cancer cells and blood cells may differ in fragmentation patterns, we investigated whether analysis of genomic positioning and nucleotide sequence at fragment ends can reveal the presence of tumor DNA in blood and aid cancer diagnostics. We analyzed whole genome sequencing data from >2700 plasma...

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Literature Corpus work
30fc7c2b-5ffd-5e47-9230-fe50051c4410
DOI
10.1101/2021.04.23.21255935
Open publication

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Analysis of fragment ends in plasma DNA from patients with cancerDOI 10.1101/2021.04.23.21255935
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