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Article

Transcriptomic Analysis Reveals JAK2/MPL-Independent Effects of Calreticulin Mutations in a C. elegans Model.

Cells - 2 Jan 2023

Guijarro-Hernández Ana, Eder-Azanza Laura, Hurtado Cristina, Navarro-Herrera David, Ezcurra Begoña, Novo Francisco Javier, Cabello Juan, Vizmanos José Luis

Abstract excerpt

There is growing evidence that Ph-negative myeloproliferative neoplasms (MPNs) are disorders in which multiple molecular mechanisms are significantly disturbed. Since their discovery, CALR driver mutations have been demonstrated to trigger pathogenic mechanisms apart from the well-documented activation of JAK2/MPL-related pathways, but the lack of experimental models harboring CALR mutations in a JAK2/MPL...

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Identifiers

PMID: 36611979
DOI: 10.3390/cells12010186
PMCID: PMC9818371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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