Article
Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms in mice.
Blood - 2 Jul 2020
Shide Kotaro, Kameda Takuro, Kamiunten Ayako, Ozono Yoshinori, Tahira Yuki, Yokomizo-Nakano Takako, Kubota Sho, Ono Masaya, Ikeda Kazuhiko, Sekine Masaaki, Akizuki Keiichi, Nakamura Kenichi, Hidaka Tomonori, Kubuki Yoko, Iwakiri Hisayoshi, Hasuike Satoru, Nagata Kenji, Sashida Goro, Shimoda Kazuya
Abstract excerpt
Mutations in JAK2, myeloproliferative leukemia virus (MPL), or calreticulin (CALR) occur in hematopoietic stem cells (HSCs) and are detected in more than 80% of patients with myeloproliferative neoplasms (MPNs). They are thought to play a driver role in MPN pathogenesis via autosomal activation of the JAK-STAT signaling cascade. Mutant CALR binds to MPL, activates downstream MPL signaling cascades, and induces...
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