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Article

Myeloproliferative Neoplasm-like Mutations of Calreticulin Induce Phenotypes Associated with Calreticulin Dysfunction in C. elegans.

International journal of molecular sciences - 29 Oct 2024

Guijarro-Hernández Ana, Hurtado Cristina, Urizar-Compains Estibaliz, Ezcurra Begoña, Galiana-Sáenz Alberto, Baquero Enrique, Cabello Juan, Vizmanos José Luis

Abstract excerpt

In previous research, we created a C. elegans model with homozygous mutations in calreticulin similar to those found in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF), two myeloproliferative neoplasms (MPNs). This model, lacking JAK orthologs, enabled us to examine the transcriptomic effects caused by mutant calreticulin without the influence of JAK/STAT activation, the primary...

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Identifiers

PMID: 39519157
DOI: 10.3390/ijms252111606
PMCID: PMC11546369

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Myeloproliferative Neoplasm-like Mutations of Calreticulin Induce Phenotypes Associated with Calreticulin Dysfunction in C. elegans.PMID 39519157Read ↗

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