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Article

Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs.

Blood - 15 Sept 2022

Jutzi Jonas S, Marneth Anna E, Ciboddo Michele, Guerra-Moreno Angel, Jiménez-Santos María José, Kosmidou Anastasia, Dressman James W, Liang Hongyan, Hamel Rebecca, Lozano Patricia, Rumi Elisa, Doench John G, Gotlib Jason, Krishnan Anandi, Elf Shannon, Al-Shahrour Fátima, Mullally Ann

Abstract excerpt

Calreticulin (CALR) mutations are frequent, disease-initiating events in myeloproliferative neoplasms (MPNs). Although the biological mechanism by which CALR mutations cause MPNs has been elucidated, there currently are no clonally selective therapies for CALR-mutant MPNs. To identify unique genetic dependencies in CALR-mutant MPNs, we performed a whole-genome clustered regularly interspaced short palindromic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35763665
DOI: 10.1182/blood.2022015629
PMCID: PMC9479036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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