Article
hiPSC-derived GRN-deficient astrocytes delay spiking activity of developing neurons.
Neurobiology of disease - 1 Jun 2023
Lee Christopher, Frew Jonathan, Weilinger Nicholas L, Wendt Stefan, Cai Wenji, Sorrentino Stefano, Wu Xiujuan, MacVicar Brian A, Willerth Stephanie M, Nygaard Haakon B
Abstract excerpt
Frontotemporal dementia (FTD) refers to a group of neurodegenerative disorders that are characterized by pathology predominantly localized to the frontal and temporal lobes. Approximately 40% of FTD cases are familial, and up to 20% of these are caused by heterozygous loss of function mutations in the gene encoding for progranulin (PGRN), GRN. The mechanisms by which loss of PGRN leads to FTD remain incompletely...
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