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Glia in FTLD-GRN: from supporting cast to leading role.

The Journal of clinical investigation - 15 Mar 2023

Pinarbasi Emile S, Barmada Sami J

Abstract excerpt

A subset of the neurodegenerative disease frontotemporal lobar degeneration (FTLD) is caused by mutations in the progranulin (GRN) gene. In this issue of the JCI, Marsan and colleagues demonstrate disease-specific transcriptional profiles in multiple glial cell lineages - astrocytes, microglia, and oligodendroglia - that are highly conserved between patients with FTLD-GRN and the widely used Grn-/- mouse model....

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Frontotemporal Dementia
Frontotemporal Lobar Degeneration
Intercellular Signaling Peptides and Proteins
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurodegenerative Diseases

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PMID: 36919702
DOI: 10.1172/JCI168215
PMCID: PMC10014098

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