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Article

The genetic landscape of early-onset Alzheimer's disease in China.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2025

Qin Wei, Li Fang-Yu, Liu Wen-Ying, Li Ying, Cao Shu-Man, Wei Yi-Ping, Li Yan, Wang Qi, Wang Qi-Geng, Jia Jian-Ping

Abstract excerpt

INTRODUCTION: Research on somatic and germline mutations in Chinese individuals with early-onset Alzheimer's disease (EOAD) has been limited. METHODS: We conducted whole-genome sequencing of blood DNA from 108 patients with EOAD and 116 controls. The analysis included somatic and germline mutations across coding and non-coding regions, mutational signature determination, pathway enrichment identification, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39907198
DOI: 10.1002/alz.14486
PMCID: PMC11851144

Genes

APP
DOCK3
PCSK5
PDE4D
TUBB4B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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