Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy

9 Jun 2017

Abstract excerpt

Abstract Genetically engineered pigs are a promising source for islet cell transplantation in type 1 diabetes, but the strong human anti-pig immune response prevents its successful clinical application. Here we studied the efficacy of neonatal porcine islet-like cell clusters (NPICCs) overexpressing LEA29Y, a high-affinity variant of the T cell co-stimulation inhibitor CTLA-4Ig, to engraft and restore...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pancreatic function and diabetes
Share to Pluripotent Stem Cells Research
Share to Xenotransplantation and immune response

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28620237
DOI: 10.1038/s41598-017-03913-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapyPMID 28620237Read ↗

Xenografted Islet Cell Clusters From <i>INS</i>LEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized MiceSemantic proximity Read ↗

Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified PigsSemantic proximity Read ↗

XenotransplantationSemantic proximity Read ↗

Engineering sialylation in pigs: A promising strategy for overcoming xenograft rejection and revolutionizing organ transplantationSemantic proximity Read ↗

Engineering human stem cell-derived islets to evade immune rejection and promote localized immune toleranceSemantic proximity Read ↗

Generation of GGTA1−/−β2M−/−CIITA−/− Pigs Using CRISPR/Cas9 Technology to Alleviate Xenogeneic Immune ReactionsSemantic proximity Read ↗

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes—Chapter 2b: genetically modified source pigsSemantic proximity Read ↗

HLA-G1+ Expression in GGTA1KO Pigs Suppresses Human and Monkey Anti-Pig T, B and NK Cell Responses.Semantic proximity Read ↗

Developments in kidney xenotransplantationSemantic proximity Read ↗

Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantationSemantic proximity Read ↗

Alternative Immunomodulatory Strategies for Xenotransplantation: CD80/CD86-CTLA4 Pathway-Modified Immature Dendritic Cells Promote Xenograft SurvivalSemantic proximity Read ↗

An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native PigsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.