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Article

Sputum macrophage diversity and activation in asthma: Role of severity and inflammatory phenotype.

Allergy - 1 Mar 2021

Tiotiu Angelica, Zounemat Kermani Nazanin, Badi Yusef, Pavlidis Stelios, Hansbro Philip M, Guo Yi-Ke, Chung Kian Fan, Adcock Ian M

Abstract excerpt

BACKGROUND: Macrophages control innate and acquired immunity, but their role in severe asthma remains ill-defined. We investigated gene signatures of macrophage subtypes in the sputum of 104 asthmatics and 16 healthy volunteers from the U-BIOPRED cohort. METHODS: Forty-nine gene signatures (modules) for differentially stimulated macrophages, one to assess lung tissue-resident cells (TR-Mφ) and two for their...

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PMID: 32740964
DOI: 10.1111/all.14535

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