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Article

Biochemical Analysis Leads to Improved Orthogonal Bioluminescent Tools.

Chembiochem : a European journal of chemical biology - 14 Mar 2023

Williams Sierra J, Gewing-Mullins Jordan A, Lieberman Whitney K, Kolbaba-Kartchner Bethany, Iqbal Reema, Burgess Hana M, Colee Clair M, Ornelas Marya Y, Reid-McLaughlin Edison S, Mills Jeremy H, Prescher Jennifer A, Leconte Aaron M

Abstract excerpt

Engineered luciferase-luciferin pairs have expanded the number of cellular targets that can be visualized in tandem. While light production relies on selective processing of synthetic luciferins by mutant luciferases, little is known about the origin of selectivity. The development of new and improved pairs requires a better understanding of the structure-function relationship of bioluminescent probes. In this...

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PMID: 36592373
DOI: 10.1002/cbic.202200726
PMCID: PMC10265744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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