Article

Design of optical imaging probes by screening of diverse substrate libraries directly in disease tissue extracts

2020-06-08

Abstract excerpt

Fluorescently-quenched probes that are specifically activated in the cancer microenvironment have great potential application for diagnosis, early detection and surgical guidance. These probes are often designed to target specific enzymes associated with disease by direct optimization using single purified targets. However, this can result in painstaking chemistry efforts to produce a probe with suboptimal perform...

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Literature Corpus work: c8ccd1a2-fd5f-500e-bb89-cb3a1e69234e
DOI: 10.1101/2020.06.08.140947

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