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Article

A Cell-Permeant Nanobody-Based Degrader That Induces Fetal Hemoglobin

14 Dec 2022

Abstract excerpt

Proximity-based strategies to degrade proteins have enormous therapeutic potential in medicine, but the technologies are limited to proteins for which small molecule ligands exist. The identification of such ligands for therapeutically relevant but "undruggable" proteins remains challenging. Herein, we employed yeast surface display of synthetic nanobodies to identify a protein ligand selective for BCL11A, a...

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PMID: 36589886
DOI: 10.1021/acscentsci.2c00998

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