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Article

A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing

28 Nov 2024

Abstract excerpt

) hemoglobin switch and is exploited in gene-based therapy for hemoglobin disorders. Because of reliance on ex vivo cell manipulation and marrow transplant, such therapies cannot lessen disease burden. To develop new small-molecule approaches, we investigated the state of BCL11A protein in erythroid cells. We report that tetramer formation mediated by a single zinc finger (ZnF0) is required for production of...

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PMID: 39607926
DOI: 10.1126/science.adp3025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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