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Article

A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules.

Cell - 8 Sept 2006

Banaszynski Laura A, Chen Ling-Chun, Maynard-Smith Lystranne A, Ooi A G Lisa, Wandless Thomas J

Abstract excerpt

Rapid and reversible methods for perturbing the function of specific proteins are desirable tools for probing complex biological systems. We have developed a general technique to regulate the stability of specific proteins in mammalian cells using cell-permeable, synthetic molecules. We engineere...

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Identifiers

PMID: 16959577
DOI: 10.1016/j.cell.2006.07.025
PMCID: PMC3290523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16959577-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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