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The Fetal-to-Adult Hemoglobin Switch — Mechanism and Therapy

4 Jun 2025

Abstract excerpt

The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for mutant β-globin.

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Share to Erythrocyte Function and Pathophysiology
Share to Hemoglobinopathies and Related Disorders
Share to Neonatal Health and Biochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40466067
DOI: 10.1056/nejmra2405260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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