Article
The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients.
Iranian journal of immunology : IJI - 1 Dec 2022
Darai Masumeh, Soleimanian Saeede, Yaghobi Ramin, Kazemi Kourosh, Nikeghbalian Saman, Azarpira Negar
Abstract excerpt
BACKGROUND: Cytomegalovirus (CMV) reinfection in transplant patients has been associated with graft loss and decreased patient survival. In this regard, the HLA-G molecule has the immunomodulatory characteristic and its soluble isoforms have important roles in immunity to viruses. The 14bp insertion/deletion polymorphism impacts HLA-G mRNA stability. Regarding the HLA-E molecule, two nonsynonymous alleles,...
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