Article
HLA-E*01:01 allele is associated with better response to anti-HCV therapy while homozygous status for HLA-E*01:03 allele increases the resistance to anti-HCV treatments in frequently transfused thalassemia patients.
Human immunology - 1 Jul 2022
Hosseini Ehteramolsadat, Sarraf Kazerooni Ehsan, Azarkeivan Azita, Sharifi Zohreh, Shahabi Majid, Ghasemzadeh Mehran
Abstract excerpt
BACKGROUND: HLA-E binding to NKG2A/CD94 induces inhibitory signals that modulate NK cells cytotoxicity against infected targets. HCV-derived peptides stabilize HLA-E molecule that favours its higher expression. However, HLA-E stability and expression vary in different genotypes where the presence of HLA-E*01:03 allele is associated with higher HLA-E expression on targets that enhances NK cells inhibition and...
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