Article
HLA-E(⁎)01:03 Allele in Lung Transplant Recipients Correlates with Higher Chronic Lung Allograft Dysfunction Occurrence.
Journal of immunology research - 1 Jan 2016
Di Cristofaro Julie, Pelardy Mathieu, Loundou Anderson, Basire Agnès, Gomez Carine, Chiaroni Jacques, Thomas Pascal, Reynaud-Gaubert Martine, Picard Christophe
Abstract excerpt
Lung transplantation (LTx) is a valid therapeutic option for selected patients with end-stage lung disease. HLA-E seems to play a major role in the immune response to different viral infections and to affect transplantation outcome, in Hematopoietic Stem Cell Transplantation, for example. Two nonsynonymous alleles, HLA-E(⁎)01:01 and HLA-E(⁎)01:03, have functional differences, involving relative peptide affinity,...
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