Article
Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation.
International journal of molecular sciences - 5 Nov 2017
Guberina Hana, Tomoya Michita Rafael, Dolff Sebastian, Bienholz Anja, Trilling Mirko, Heinemann Falko M, Horn Peter A, Kribben Andreas, Witzke Oliver, Rebmann Vera
Abstract excerpt
The expression modulation of the immunosuppressive non-classical Human leukocyte antigen-G (HLA-G) molecule and its soluble isoforms is an immune evasion strategy being deployed by cytomegalovirus (CMV). The +3142 C>G single nucleotide polymorphism (SNP) located within the 3' untranslated region (3'UTR) is of crucial importance for the regulation of HLA-G expression. Therefore, we analyzed the influence of the...
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